---
product_id: 3558979
title: "Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets"
brand: "doctor's best"
price: "₨1746"
currency: SCR
in_stock: true
reviews_count: 9
category: "Doctor's Best"
url: https://www.desertcart.sc/products/3558979-doctors-best-sam-e-400-mg-vegan-gluten-free-soy
store_origin: SC
region: Seychelles
---

# Vegan, Non-GMO, Gluten & Soy Free 400 mg potent SAMe per tablet Supports mood, cognition & joint health Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets

**Brand:** doctor's best
**Price:** ₨1746
**Availability:** ✅ In Stock

## Summary

> 💼 Elevate your mood, joints & focus—because thriving is non-negotiable.

## Quick Answers

- **What is this?** Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets by doctor's best
- **How much does it cost?** ₨1746 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.sc](https://www.desertcart.sc/products/3558979-doctors-best-sam-e-400-mg-vegan-gluten-free-soy)

## Best For

- doctor's best enthusiasts

## Why This Product

- Trusted doctor's best brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Multi-System Support:** Enhances neurotransmitter synthesis, promotes joint comfort, and boosts liver detoxification with powerful methylation.
- • **Clean & Conscious Formula:** Vegan, gluten-free, soy-free, and non-GMO—perfect for the mindful professional prioritizing clean wellness.
- • **Trusted Quality from Italy:** Utilizes the highest quality Italian SAMe, ensuring unmatched purity and potency backed by 18+ clinical trials.
- • **Clinically Proven Double Strength:** 400 mg of pharmaceutical-grade SAMe delivers maximum bioactive S,S isomer for superior mood and joint support.
- • **Enteric Coated for Optimal Absorption:** Special coating protects SAMe from stomach acid, reducing discomfort and maximizing bioavailability.

## Overview

Doctor's Best SAM-e 400 mg offers a premium, enteric-coated formula delivering high-purity S,S isomer SAMe to support mood enhancement, cognitive function, joint comfort, and liver health. Vegan, gluten-free, and soy-free, this supplement is backed by decades of clinical research and crafted with pharmaceutical-grade Italian SAMe for maximum efficacy and gentle digestion.

## Description

SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none. S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones. The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market. SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.* SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.* SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.*

Review: Works well for joint pain and mild depression - I tried a different brand of SAM-E about a year ago. Began having stomach cramps soon after. Tried Doctors Best and found I no longer had stomach issues. I suffer from joint pain in the legs and mild depression. Noticed a major relief in joint pain and a better state of mind with a reduction in my depression. I buy a 60-count box once a month. 2 tabs a day. While I would like to double the daily intake, forty dollars a month is the most I can afford. My honest opinion, it relieves joint pain, and puts me in a better state of mind, without getting into SSRI's or opiates. The only minus is the price.
Review: Good Quality for Price - I used this product on my veterinarian's recommendation, for my 17 year old dog who was losing his step and acting a little grumpy. Along with pain meds, this really made a difference I felt. I decided to try it myself and I was surprised when I seemed to feel my usual winter blues, so much less severely. Be aware that it takes a couple MONTHS to feel a noticeable difference. But, your body needs this anyway so it certainly will do no harm to try it. Always let your doctor and/or pharmacist know you're on it though. There's some moderate interactions mostly of the "makes this medicine slightly less effective" variety. Always look for SAM-e with the foil blister pac and make sure you're giving it without food. It's sensitive to light, heat, and moisture. I've tried a few brands and right now Doctor's Best strikes the sweet spot between reliable quality and price. This is one supplement that you really HAVE to pay for effectiveness.

## Features

- Doctor's Best SAMe Double Strength is proven to enhance mood and promote cognitive health
- SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin and norepinephrine
- SAMe has been proven to promote joint comfort and mobility and supports liver health and detoxification
- SAMe's effectiveness has been proven with 18 controlled human trials published over 40 years
- Pharmaceutical grade, Non-GMO, Gluten Free, Vegan

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B004YLAXOE |
| Best Sellers Rank | #20,731 in Health & Household ( See Top 100 in Health & Household ) #640 in Blended Vitamin & Mineral Supplements #1,760 in Sales & Deals #1,969 in Diet & Sports Nutrition |
| Customer Reviews | 4.6 4.6 out of 5 stars (3,474) |
| Date First Available  | April 29, 2011 |
| Is Discontinued By Manufacturer  | No |
| Item model number  | DRB-00252 |
| Manufacturer  | Doctor’s Best, Inc |
| Product Dimensions  | 3.25 x 2 x 6.13 inches; 3.2 ounces |

## Product Details

- **Brand:** Doctor's BEST
- **Diet Type:** Gluten Free, Vegan
- **Flavor:** Unflavored
- **Item Form:** Tablet
- **Item Weight:** 0.2 Pounds
- **Item dimensions L x W x H:** 3.25 x 2 x 6.13 inches
- **Primary Supplement Type:** multivitamin
- **Product Benefits:** Detoxing
- **Special Ingredients:** Amino Acid
- **Unit Count:** 60 Count

## Images

![Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets - Image 1](https://m.media-amazon.com/images/I/61qTxsnqhPL.jpg)

## Available Options

This product comes in different **Size, Flavor** options.

## Questions & Answers

**Q: Is each tablet packaged in foil?**
A: The tablets are in a ten count foil blister pack. Each pill has it's own sealed compartment. I am an RN and this is like medical grade packaging. Safe.

**Q: Could this cause you to feel warm or hot and sometimes dizziness?**
A: SAM-e, especially when combined with other medications, has a potential to contribute to Seratonin Syndrome, which can cause temperature disregulation and dizziness. This is a supplement that effects the function of your brain and neural pathways. Please make sure you use it as directed and preferrably under the care of someone who is knowledgeable on the subject if you have not done your own research. If any adverse reactions occur, stop taking the supplement and please talk to your doctor about it. There is the potential for very bad reactions if Seratonin builds up too much. 

Every person's brain is unique and will react in different ways. Nothing involved in brain support supplements are a one-size-fits-all.

**Q: how long does it take to start working**
A: I have taken SAM-e for 15 years very successfully. It has never failed to work for me, unlike Rx antidepressants and other supplements (like St John's Wort). In the last year I have increased from 1 400 mg pill daily to 2. I'm in my 60s and i just seem to feel better with more. (It is also anti-aging because it helps correct the mistakes that accumulate in our DNA). In my experience SAM-e works very quickly. If I need a boost, I take an extra dose and I feel better within 1-2 hours. You can take up to 1600 mg in a day (four 400 mg pills) with no problem. If I know I'm going to have a stressful day I will head off problems by taking 2 upon awakening, and then 1-2 more later in the day, when I can be sure of an empty stomach. It's important to take SAM-e at least 30 minutes before food, or 2 hours after, for best absorption.

**Q: How do these compare to nature made? That's my usual.**
A: For me, I like Nature Made so much better. Nature Made worked for my husband and I. We switched to these in an effort to save money and within two weeks of the switch we both started hurting again. Also these came with several of the bubbles punctured and the pills were different colors, within the pack. If you read some of the recent reviews, you’ll see others had some of the same issues and far as punctured blister packs and color changes within the box. We switched back to Nature Made, which was the brand our Orthapedic doctor had recommended.

## Customer Reviews

### ⭐⭐⭐⭐⭐ Works well for joint pain and mild depression
*by A***R on August 23, 2025*

I tried a different brand of SAM-E about a year ago. Began having stomach cramps soon after. Tried Doctors Best and found I no longer had stomach issues. I suffer from joint pain in the legs and mild depression. Noticed a major relief in joint pain and a better state of mind with a reduction in my depression. I buy a 60-count box once a month. 2 tabs a day. While I would like to double the daily intake, forty dollars a month is the most I can afford. My honest opinion, it relieves joint pain, and puts me in a better state of mind, without getting into SSRI's or opiates. The only minus is the price.

### ⭐⭐⭐⭐⭐ Good Quality for Price
*by R***E on September 21, 2025*

I used this product on my veterinarian's recommendation, for my 17 year old dog who was losing his step and acting a little grumpy. Along with pain meds, this really made a difference I felt. I decided to try it myself and I was surprised when I seemed to feel my usual winter blues, so much less severely. Be aware that it takes a couple MONTHS to feel a noticeable difference. But, your body needs this anyway so it certainly will do no harm to try it. Always let your doctor and/or pharmacist know you're on it though. There's some moderate interactions mostly of the "makes this medicine slightly less effective" variety. Always look for SAM-e with the foil blister pac and make sure you're giving it without food. It's sensitive to light, heat, and moisture. I've tried a few brands and right now Doctor's Best strikes the sweet spot between reliable quality and price. This is one supplement that you really HAVE to pay for effectiveness.

### ⭐⭐⭐⭐⭐ Worked for me!
*by J***L on November 13, 2013*

Well it worked for me! I discovered Sam-e while doing some research on my own and decided to give it a try for my mild to moderate depression problems. It worked for me after about a week I started to notice a difference in my mood, I had more energy, and I was able to concentrate again. A few weeks after that i decided i didn't need it anymore and went off of it and a few days later I woke up feeling terrible with the same unpleasant feelings I had before I started taking it. Needless to say that night I went to the supermarket and bought some more. Now I just buy it from amazon because I know I need it and it offers the best value. I'll happily dish out forty bucks every two months if it helps me feel like this. I will note though that at first when I was switching brands I did have some gastrointestinal discomfort that was really unpleasant at first. It lasted off and on about three weeks, but then it stopped and I haven't had it since. I changed my diet to make sure I got about the same amount of fiber everyday to try and combat those problems and for me that seemed to work. I take one 400mg tablet every morning on an empty stomach and wait thirty minutes to an hour before eating anything. One time I ate something a few minutes after taking it and I did vomit so there's your warning, they actually do mean it when they say to wait to eat. Overall, I'm extremely happy with this product and if you don't believe these reviews look up some scholarly articles on it and the research speaks for itself, I believe they actually prescribe it for mild to moderate depression in countries like Germany. I've also read that st. john's wort works too for depression problems, but I've never tried it. A warning about st. john's though it can mess with the efficacy of birth control pills so I would be cautious about st. john's wort if you're taking birth control.

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*Product available on Desertcart Seychelles*
*Store origin: SC*
*Last updated: 2026-02-28*