--- product_id: 59482166 title: "Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed" brand: "nature's trove" price: "₨2217" currency: SCR in_stock: true reviews_count: 12 category: "Nature's Trove" url: https://www.desertcart.sc/products/59482166-natures-trove-sam-e-400mg-120-enteric-coated-caplets-2 store_origin: SC region: Seychelles --- # Vegan, Non-GMO, Gluten & Soy free 400mg potent dose Enteric coated for max absorption Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed **Brand:** nature's trove **Price:** ₨2217 **Availability:** βœ… In Stock ## Summary > πŸ’₯ Elevate your mood & mobility with Nature’s Trove SAM-e β€” because your wellness deserves the best! ## Quick Answers - **What is this?** Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed by nature's trove - **How much does it cost?** ₨2217 with free shipping - **Is it available?** Yes, in stock and ready to ship - **Where can I buy it?** [www.desertcart.sc](https://www.desertcart.sc/products/59482166-natures-trove-sam-e-400mg-120-enteric-coated-caplets-2) ## Best For - nature's trove enthusiasts ## Why This Product - Trusted nature's trove brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - β€’ **Dual-Box Value Pack:** 120 caplets total, cold-form blister packed for freshness and convenience. - β€’ **Advanced Enteric Coating:** Ensures optimal absorption where it countsβ€”beyond the stomach acid barrier. - β€’ **Clean & Conscious Formula:** Vegan, Kosher, Non-GMO, soy & gluten free for mindful wellness. - β€’ **Trusted Science & Expertise:** Two decades of research perfecting SAM-e for mood, joint, and liver support. - β€’ **Clinically Potent 400mg Dose:** Power your mood & joints with a scientifically backed strength. ## Overview Nature's Trove SAM-e 400mg delivers a premium, enteric-coated amino acid supplement designed to support mood balance, joint flexibility, and liver health. With 120 vegan, kosher, non-GMO caplets in a freshness-sealed blister pack, this scientifically refined formula offers a clean, allergen-free option trusted by thousands for daily wellness optimization. ## Description Buy Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed on desertcart.com βœ“ FREE SHIPPING on qualified orders Review: Fast and good source of nutritional supplements. - SAMe, S-adenyl L Methionine has been noted by research to improve cartilage formation. As you see from the name, it is essentially an amino acid. I purchased the 200 and 400 mg quantities. The product is a molecule that is synthesized by some yeasts - bakers' yeast is most common. While I cannot personally double-blind test its effectiveness, scientific evaluation has, and has shown it to increase cartilage recovery. I nearly completely re-tore a long-previously reconstructed knee , and, as my other knee had also been damaged by significant aerial mistakes and landings I sought more than just the usual chondroitin, MSM, etc. Having seen live images of the cartilage damage in my knees, and exploring the research, I strongly feel that SAMe is worth purchase. This brand is naturally-sourced - a good selling point, and it is reasonably priced on comparison to many others. SAMe is also sold as neuroactive, due to its part in the synthesis of serotonin, which was a matter of concern. Serotonin is synthesized through the production and synthesis of this molecule, in great part by mutualist symbiotic enteric microorganisms. Again, because this is natural, it is almost certainly a good nutritional supplement, as enteric organisms tend to change quickly in response to different dietary intake. Thus, it promotes more regular synthesis of one of the most important neurotransmitters. Due to the highly stressful period in which all of us are immersed, I haven't looked deeper into that neurological issue, although we DO know a few things about it. Serotonin itself cannot cross into the brain, and that produced in the intestines affects other physiological processes - we need it. But excess serotonin production in the brain affects males and females differently and the brain's feedback processes tend to act to restore normality (it's possible that some individuals may experience persistent insufficiency OR excess, but those are a small minority. .If you suspect such long-term problem, do consult a medical therapist - Psychologists can refer those with metabolic problems of persistent types to psychiatrists who can test for such problems. But recognize that serotonin understanding is in its infancy, and the past with its SSRIs and other quite invasive drugging, is like using a hammer to fix a computer board or a brain) That, in short, is why I do NOT recommend that people seek neurotropic drugs - from alcohol to other drugs, we interfere with or destroy natural functioning, which it's sometimes better to address ONLY through physical, mental, social activities. SAMe is, though, pretty much methionine, a food, and we may often be deficient in that amino acid - which is why it can improve cartilage formation, as well as other variables like digestion. So, explore the effects of ANYTHING you ingest, and DO NOT just take things because of inane claims unsupported by rigorous scientific research. This company was extremely responsive (FAST!) to my desertcart order, and, so, with its component sourcing, seems a great place from which to purchase nutritional products. While I have experienced reduced pain , I had also been expanding the exercise of joints I injured and reinjured, and so cannot honestly evaluate sensations like pain reduction for others. I use less aspirin since the combination of SAMe, the natural healing process, and slow increase of exercise of affected joints, and as usual recommend any safe reduction of NSAID use. SAMe does not have the deleterious side effects of NSAIDs. Review: Outstanding Product - This SAM-e is the only one that works for our son with ASD level 1/anxiety/depression. I don't understand how one brand can be so much better than another. We ran out recently and I purchased a different brand in a local vitamin shop and he had no idea that the brand was different. When our new shipment of Nature's Trove came in I could notice a drastic difference in him. I didn't say anything, but he told me on his own that his brain was clear and that his anxiety was gone. ## Features - PREMIUM QUALITY: Nature's Trove is committed to making the highest quality SAM-e supplements affordable for all consumers. We start with raw material that contains the highest level of the active S.S. Isomer, and manufacture it under strictly controlled GMP conditions. The caplets are enteric coated for optimal absorption, and blister packaged for maximum freshness. Our product is free from allergens, artificial coloring and flavors; suitable for vegan, GMO free, and Kosher certified. - EXPERTISE & INDUSTRY LEADERSHIP: Our experts have been working with SAM-e (s-adenosylmethionine) and perfecting its formulation for over 2 decades. We are pleased to present a product that is backed by an incredible amount of science, literature, and research studies. - MOOD AND WELLBEING: SAM-e may help promote mood and well-being. - JOINT HEALTH: SAM-e may help maintain joint flexibility & mobility. - LIVER HEALTH: SAM-e may support healthy liver functions. ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B079Z9XZRM | | Age Range Description | All Ages | | Allergen Information | Gluten Free, Soy Free | | Best Sellers Rank | #3,382 in Health & Household ( See Top 100 in Health & Household ) #34 in Blended Vitamin & Mineral Supplements #410 in Herbal Supplements | | Brand | Nature's Trove | | Brand Name | Nature's Trove | | Color | Red | | Container Type | Box | | Customer Reviews | 4.6 out of 5 stars 13,588 Reviews | | Dosage Form | Capsule | | Flavor | Unflavored | | Global Trade Identification Number | 00850056289061 | | Item Dimensions | 4.5 x 3.13 x 5.25 inches | | Item Form | Caplet | | Item Weight | 0.36 g | | Item dimensions L x W x H | 4.5 x 3.13 x 5.25 inches | | Manufacturer | Nature's Trove | | Manufacturer Part Number | TRSAM460X2 | | Material Features | GMO Free, Gluten Free, Kosher Certified, Vegan | | Material Type Free | en_AE | | Number of Items | 2 | | Product Benefits | Bone & Joint Support, Liver Health Support | | Special Ingredients | Amino Acid | | Specific Uses For Product | Laboratory | | Total Servings Per Container | 60 | | UPC | 850056289061 | | Unit Count | 120 Count | ## Product Details - **Age Range (Description):** All Ages - **Brand:** Nature's Trove - **Flavor:** Unflavored - **Item Form:** Caplet - **Item Weight:** 0.36 g - **Item dimensions L x W x H:** 4.5 x 3.13 x 5.25 inches - **Package Information:** Box - **Product Benefits:** Bone & Joint Support, Liver Health Support - **Special Ingredients:** Amino Acid - **Unit Count:** 120 Count ## Images ![Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed - Image 1](https://m.media-amazon.com/images/I/81TkT02B9fL.jpg) ![Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed - Image 2](https://m.media-amazon.com/images/I/813nOuJjT9L.jpg) ![Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed - Image 3](https://m.media-amazon.com/images/I/81cYyg8uXNL.jpg) ![Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed - Image 4](https://m.media-amazon.com/images/I/81zIYrNYoiL.jpg) ![Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed - Image 5](https://m.media-amazon.com/images/I/714En4zgBuL.jpg) ## Available Options This product comes in different **Size** options. ## Questions & Answers **Q: What is the net yield of sam-e? 400 or 200mg? if 400mg s-adenosylmethionine tosylate disulfate then it is often a net yield of only 200mg-misleading!!** A: I ordered a bottle of Natures Trove Sam-e 400mg.When it arrived the first thing I noticed on the ingredients labeling was....SAM-E 400mg from 800mg of Sam-e Tosylate Disulfate... Hmmmm. I have always taken NatureMade Sam-e which states only ( Sam-e( S-adenosylmethionine 400mg. and found it excellent and stable. It has very good enteric coating and is consistent as to when I can feel it effecting my mood and energy. I know it is a reliable brand. I am going to give Natures Trove a fair shot as the price is better..... and hope that this difference in labeling of the main ingredient does not mean anything in reference to effectiveness. Does anyone have info to clarify the labeling? **Q: where is this made?** A: Hi, Nature's Trove SAM-e is made in the USA. **Q: Does this really contain titanium dioxide? (says it "might") that's toxic!!!** A: The ingredients are on the box and yes titanium dioxide is listed. Whether it is toxic or not I have no idea. Maybe in the amount that is contained in the product might determine whether it is or not. **Q: The front cover states its a natural deritive of yeast the back of the box says theres no yeast .I called the 1800 number to ask no answere?** A: Hi, SAM-e is derived from a specific natural chemical compound found in yeast however there is no yeast in this product. I hope that answers your question. ## Customer Reviews ### ⭐⭐⭐⭐⭐ Fast and good source of nutritional supplements. *by M***M on July 15, 2020* SAMe, S-adenyl L Methionine has been noted by research to improve cartilage formation. As you see from the name, it is essentially an amino acid. I purchased the 200 and 400 mg quantities. The product is a molecule that is synthesized by some yeasts - bakers' yeast is most common. While I cannot personally double-blind test its effectiveness, scientific evaluation has, and has shown it to increase cartilage recovery. I nearly completely re-tore a long-previously reconstructed knee , and, as my other knee had also been damaged by significant aerial mistakes and landings I sought more than just the usual chondroitin, MSM, etc. Having seen live images of the cartilage damage in my knees, and exploring the research, I strongly feel that SAMe is worth purchase. This brand is naturally-sourced - a good selling point, and it is reasonably priced on comparison to many others. SAMe is also sold as neuroactive, due to its part in the synthesis of serotonin, which was a matter of concern. Serotonin is synthesized through the production and synthesis of this molecule, in great part by mutualist symbiotic enteric microorganisms. Again, because this is natural, it is almost certainly a good nutritional supplement, as enteric organisms tend to change quickly in response to different dietary intake. Thus, it promotes more regular synthesis of one of the most important neurotransmitters. Due to the highly stressful period in which all of us are immersed, I haven't looked deeper into that neurological issue, although we DO know a few things about it. Serotonin itself cannot cross into the brain, and that produced in the intestines affects other physiological processes - we need it. But excess serotonin production in the brain affects males and females differently and the brain's feedback processes tend to act to restore normality (it's possible that some individuals may experience persistent insufficiency OR excess, but those are a small minority. .If you suspect such long-term problem, do consult a medical therapist - Psychologists can refer those with metabolic problems of persistent types to psychiatrists who can test for such problems. But recognize that serotonin understanding is in its infancy, and the past with its SSRIs and other quite invasive drugging, is like using a hammer to fix a computer board or a brain) That, in short, is why I do NOT recommend that people seek neurotropic drugs - from alcohol to other drugs, we interfere with or destroy natural functioning, which it's sometimes better to address ONLY through physical, mental, social activities. SAMe is, though, pretty much methionine, a food, and we may often be deficient in that amino acid - which is why it can improve cartilage formation, as well as other variables like digestion. So, explore the effects of ANYTHING you ingest, and DO NOT just take things because of inane claims unsupported by rigorous scientific research. This company was extremely responsive (FAST!) to my Amazon order, and, so, with its component sourcing, seems a great place from which to purchase nutritional products. While I have experienced reduced pain , I had also been expanding the exercise of joints I injured and reinjured, and so cannot honestly evaluate sensations like pain reduction for others. I use less aspirin since the combination of SAMe, the natural healing process, and slow increase of exercise of affected joints, and as usual recommend any safe reduction of NSAID use. SAMe does not have the deleterious side effects of NSAIDs. ### ⭐⭐⭐⭐⭐ Outstanding Product *by B***T on June 21, 2026* This SAM-e is the only one that works for our son with ASD level 1/anxiety/depression. I don't understand how one brand can be so much better than another. We ran out recently and I purchased a different brand in a local vitamin shop and he had no idea that the brand was different. When our new shipment of Nature's Trove came in I could notice a drastic difference in him. I didn't say anything, but he told me on his own that his brain was clear and that his anxiety was gone. ### ⭐⭐⭐⭐⭐ Good quality and value! *by M***C on July 24, 2026* My favorite Sam-e! Works well and a good price with quick shipping. A+ ## Frequently Bought Together - Nature's Trove SAM-e 400mg 120 Enteric Coated Caplets (2 Boxes of 60) - Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Comfort - Cold Form Blister Packed - Sports Research Triple Strength Omega 3 Fish Oil - Burpless Fish Oil Supplement w/EPA & DHA Fatty Acids from Single-Source Wild Alaskan Pollock - 1250 mg, 90 ct --- ## Why Shop on Desertcart? - πŸ›’ **Trusted by 1.3+ Million Shoppers** β€” Serving international shoppers since 2016 - 🌍 **Shop Globally** β€” Access 737+ million products across 21 categories - πŸ’° **No Hidden Fees** β€” All customs, duties, and taxes included in the price - πŸ”„ **15-Day Free Returns** β€” Hassle-free returns (30 days for PRO members) - πŸ”’ **Secure Payments** β€” Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** β€” Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.sc/products/59482166-natures-trove-sam-e-400mg-120-enteric-coated-caplets-2](https://www.desertcart.sc/products/59482166-natures-trove-sam-e-400mg-120-enteric-coated-caplets-2) --- *Product available on Desertcart Seychelles* *Store origin: SC* *Last updated: 2026-08-10*