5HTP 400mg Griffonia Seed Extract | 240 Vegan Tablets - 8 Months Supply of Maximum Strength 5-HTP | Made in The UK by Nutravita

To clear up any confusion: It has 50mg (stated) 5-HTP and 400mg of Griffonia seed (equivalent).Listing shows similar packaging, but slightly different wording on the bottle to what you will receive. Listing says "100% Griffonia seed" while your bottle will now say "50mg Griffonia seed". The back on listing says "8:1 ratio" but your bottle will say "400mg equivalent".What does this mean?Griffonia seed, by it's natural, raw weight, has been concentrated down by a factor of 8. So 1 gram of Griffonia seed (extract) per tablet is 8 grams of raw Griffonia seed concentrated down (extracting as much of the good part you want, i.e. 5-HTP).50mg of concentrated Griffonia seed (per tablet) therefore is 400mg of raw Griffonia seed.Griffonia seed is documented as containing 20% 5-HTP by weight (in it's raw form) - 400mg therefor contains 80mg of 5-HTP, not 400mg as wording would suggest.The good news is that all sellers use Griffonia seed as the source of 5-HTP, and almost all use the raw weight of Griffonia seed to indicate the "amount" of 5-HTP.A few sellers are using strange tactics such as "double strength" which just refers to the concentration rate (16:1 vs 8:1) but the raw weight /quantity stays the same so it means nothing as the end user. I'd avoid them on principle personally as they are just trying to mislead.To save you time, the seemingly only legit "high strength" 5-HTP per tablet is 500mg (equivelant of), according to their listing: "5 HTP High Strength 500mg" by Vitzip (10 pence per tablet)These Nutravita tablets work out (currently) as 6.6 pence each, and is only marginally (100mg equivelant) less, so currently the best value for money option on Amazon, unless their price changes.The next best value is "Ultra High Strength 5HTP" by "hello pure" - roughly 7.6 pence per tablet (400mg each) but this is a 56% sale price, so they would be ridiculously over priced at the proclaimed £30 RRP, with a whopping 1.6mg of B6 added, you would be better off buying these and a cheap multi vitimin.

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Le 5-HTP est un acide aminé connu pour être un précurseur de la sérotonine, un neurotransmetteur que l'on nomme également hormone du bonheur. Au sein du système nerveux central, cette molécule est impliquée dans la régulation du sommeil, de l'appétit et de l'humeur.La sérotonine présente dans la muqueuse gastro-intestinale représente environ 80 % de la sérotonine totale de l’organisme[8]. Elle est synthétisée et stockée au niveau des cellules chromaffines. Celles-ci stockent aussi des médiateurs peptidiques (cholécystokinine,neurotensine, peptide PYY). La libération de sérotonine par exocytose joue un rôle dans la motilité intestinale. Une partie de la sérotonine du tube digestif passe dans le sang où elle est stockée dans les plaquettes sanguines. La sérotonine n’y est pas synthétisée car elle est produite seulement dans les cellules chromaffines, les neurones sérotoninergiques et les ostéoclastes du tissu osseux[9].Il a été montré que des changements de la fréquence des potentiels d’action dans les neurones sérotoninergiques centraux pouvaient retentir sur la vitesse de biosynthèse de la 5-HT dans le cerveau. L’arrivée du potentiel d’action (PA) dans la terminaison nerveuse permet une entrée de calcium. Ce calcium va permettre la libération de la sérotonine dans la fente synaptique. Une partie de la sérotonine libérée va agir sur les récepteurs post-synaptiques, permettant ainsi le transfert de l’information d’un neurone à l’autre. La sérotonine restante va soit être dégradée soit être recaptée dans le neurone par l’intermédiaire d’un transporteur pour être recyclée. Ainsi, la sérotonine contenue dans la fente synaptique diminue- ce qui stoppe la transmission du message nerveux. Si elle est contenue en trop grande quantité dans la fente synaptique, la sérotonine agit sur ses auto-récepteurs spécifiques – présents sur les terminaisons de l’axone et sur les corps cellulaires des neurones et de leurs dendrites. L’activation de ces auto-récepteurs inhibe la synthèse de la sérotonine (boucle de rétrocontrôle négative).Une hyperstimulation des récepteurs 5-HT2 pourrait favoriser l’apparition de certains symptômes de type productif et négatif des états psychotiques. La sérotonine, grâce à ses divers types de récepteurs présynaptiques et postsynaptiques, module l’activité des autres médiateurs. Elle joue un rôle déterminant dans l’adaptation.La sérotonine intervient dans des manifestations allergiques et inflammatoires. Elle joue un rôle important dans certaines maladies.Ne convient pas à tous les "gifted".

This is the second type of 5-HTP supplement that I have tried now and I must say this is the best one so far in terms of value for money. The dosage of 5-HTP in each tablet is 50mg of concentrated griffonia seed which comes from 400mg of raw seed. So, the dosages are correct despite the speculation.With these tablets I have noticed that they definitely do work when taking them on occasion, but not every single night. This is not actually recommended anyways. The feeling you get from these is not exactly drastic when taken in the evening, however you may notice that you get that natural feeling of being ready to go to sleep when you normally wouldn’t without taking them. This is the effect it has on melatonin, so I can confirm this does work, but only sometimes for whatever reason. As for the effects on serotonin (the happy hormone), it also does have a small effect here, but it does vary each time I take it. I’d say the tablets help more with sleep than they do mood, however good sleep does help boost mood. Importantly, I find that I never feel slow and sluggish the next day after taking them like if you were to take some unnatural form of sleep aid.So, how often should you take 5-HTP? well you probably shouldn’t take it every single day. Firstly, for me the effects seem to wear out when taken day after day, and there are even people who say this is not recommended to do since there are possible side effects like with any supplement. With that said, these tablets are very small and easy to take, and with 240 tablets in the bottle it should last you a very long time, and the BBE date is long enough to space the usage of them out. Hopefully this review helps.

This product is excellent value for money given the amount of pills contained. This is good because I've found I need to take about 3 pills to get any affect.A very useful product for when I'm travelling or under extra stress.