1-MNA PRO, High Strength Next-Generation NAD Supplement Precursor, NMN & NMNH Alternative NAD Supplement, 2X Double Dose, Pure Vitamin B3 Metabolite Anti Ageing, Longevity, 30 Capsules

I've been taking 1-MNA for the last month, and while there are no life-changing notices, I have noticed increased focus and improved sleep quality. My ability to concentrate on tasks has significantly enhanced, allowing me to be more productive throughout the day. Additionally, I've been falling asleep faster and experiencing deeper, more restful sleep, which has left me feeling more refreshed in the mornings. I'm curious to see if these benefits continue over time and if there are any other effects I might experience as I continue with this supplement. Overall, I'm optimistic about the potential long-term benefits.

Great

Good product✌️

As someone who's always on the lookout for ways to support my overall health, I recently came across Endotelio 1-MNA PRO, a biohacking supplement that claims to help optimize NAD+ levels. I decided to give it a try, and here's my take on it. The product claims to have a "double dose for faster effects," which is always appealing when you're looking for quick results. The fact that it's scientifically formulated and supports cellular health is also a plus in my book. The 30 easy-to-swallow capsules are a convenient size, which is a nice touch. I've been taking the supplement for a few weeks now, and I can say that I've noticed a slight increase in my energy levels and overall well-being. It's hard to say for sure if it's directly attributable to the supplement, but I'm cautiously optimistic about the effects. One thing I appreciate about Endotelio 1-MNA PRO is that it's transparent about its ingredients and formulation. The label clearly lists the active components, which is reassuring. Overall, I'd say this is a promising supplement for those looking to optimize their NAD+ levels and support their cellular health. While the results may vary from person to person, it's worth a try if you're interested in exploring biohacking and anti-aging solutions. Just be sure to consult with your healthcare provider before starting any new supplement regimen.

Did nothing at all

I’ve taken these nearly every day for nearly a week and I have noticed a few times when I take them a few minutes after I feel a drop in mood, and very slightly breathless, like I need to consciously take deep breaths, I don’t know if it’s a good sign these are working deep into my psyche but it’s not an enjoyable feeling, opposite to uplifting. I’m glad they pointed out they’re gluten free as I am gluten intolerant and I wondered if at first if the side effects I was experiencing were cos of some gluten in there, the tablets have never given me a stomach pain or cramp at all so I can rule that out. The similarities are the ‘floaty’ too relaxed feeling I get when I have gluten. As they’re the only brand I can find that make these types of supplements I tried to find information on their website, but it asks you to sign up if you want information about research etc. The Amazon page had more information about whats in these, after purchasing, I think they may have updated it unless I missed it the first time. I wouldn’t order again as I don’t like the feeling I get when I take them, I feel a bit more dazed and less stable, I have a feeling it’s cos the ingredients are working very deeply into my psyche and unconscious brain to change the cells but I don’t like the feeling at all and will look forward to when it’s effects have worn off. I’m 37 years old and very healthy BMI and health check was above average in all areas so they shouldn’t have too much work to do on me. There’s no clear list of the ingredients, it says this supplement is found in algae and green tea (I drink green tea everyday and take chlorella tablets regularly and never have these side effects at all) and they’ve used as little ingredients as poss, but no clear list or any list of exactly what is in there. So I wouldn’t take them again as for me, the negatives I’ve experienced and found, outweigh what they say are the positives, I’m not able to confirm or notice the positives but I do believe after some 20 minutes or so despite still feeling the negative side effects I explained I do feel my jaw is more relaxed and my cells do feel more soothed, I don’t know for certain if it’s even because of these or because of the effect a drop in mood had on me. Maybe I’ll take them before bed so I can function normally during the day until I finish them.

These capsules come in a small, darkened plastic bottle inside a card box. The capsules are fairly small and easy to swallow with a glass of water leaving no aftertaste. You only need one capsule per day, so this is a month's supply. The cost seems quite high but if it has the anti-aging properties shown in blue zone areas it would be worth it. These capsules would be a good supplement to take to kick start a new healthy eating regime, but it would be no use wasting your money on them if you were not going to adopt the healthy lifestyles of the people in the blue zones to optimise the results. There is good information on the packaging including ingredients list and directions for use. They need to be consumed within 16 months. I do eat healthily and exercise regularly so I will be taking the full course of these capsules to complement this, and I am hoping for good results!

I have taken both NR and NMN for years as a way to increase my NAD+ levels as I age to improve my longevity and healthspan. Strangely, I had never heard of 1-MNA being researched for the same effects, or discussed in longevity communities. From my research since, it appears that 1-MNA does not significantly raise NAD+ levels directly. Its main action is to encourage the production of prostacyclin, which stops platelets from sticking together, preventing clotting, and produces an anti-inflammatory effect. This primarily supports the health of blood vessels and can reduce the risk of atherosclerosis. It indirectly affects NAD+ by effectively reducing the activity of an enzyme called NNMT (Nicotinamide N-methyltransferase). NNMT reduces the availability of nicotinamide for NAD+ production, so by reducing the activity of NNMT, it effectively means there is more nicotinamide available to convert into NAD+. That nicotinamide is then converted to NMN, and that NMN is then converted to NAD+. Taking NMN and NR supplements on the other hand has a much more direct ability to increase NAD+. NMN is converted into NAD+ once it enters a cell, and NR is converted to NMN before it is then converted to NAD+. Because there are fewer steps to convert to NAD+ when taking both NMN and NR, much more of the supplement goes towards producing a larger increase in NAD+. From my reading, it does appear that there are benefits to using 1-MNA, but specifically for NAD+ production, which is a major part of the marketing for this supplement, it is inferior to both NR (Nicotinamide riboside) and NMN (Nicotinamide mononucleotide). It is also priced just as high as both NR and NMN. So for effectively the same cost, you get a smaller increase in NAD+. If this supplement were, for instance, half the price, it would be more reasonable. As it stands, while this supplement might do what it says it should do, it is an expensive alternative to the vastly superior NR and NMN supplements available on the market.

Après 15 jours de prise de ce complément alimentaire, je peux témoigner de son efficacité. Il ne m'a pas causé de problèmes gastro-intestinaux et je me sens plus énergique. Je recommande vivement.

Mi piace ingegnarmi a cercare modi utili a contrastare i segni del tempo e mantenere una pelle sana e luminosa. Ho provato diverse creme e sieri, ma ultimamente ho deciso di concentrarmi sulla salute cellulare dall'interno, assumendo un integratore. La mia scelta è caduta su Endotelio 1-MNA PRO, un prodotto che promette di ottimizzare i livelli di NAD+, una molecola importante per la produzione di energia e la riparazione cellulare. Devo ammettere che ero un po' scettica all'inizio, ma dopo due settimane di utilizzo ho notato un'innegabile differenza. La mia pelle appare più tonica e compatta, con rughe meno visibili. Inoltre, mi sento più energica e vitale. ●Cosa mi piace di Endotelio 1-MNA PRO: ✔Ingredienti: la formula contiene una doppia dose di MNA, un precursore del NAD+, oltre a vitamine e minerali che supportano la salute cellulare. ✔Biodisponibilità: l'MNA è incapsulato in una tecnologia brevettata che ne aumenta l'assorbimento da parte dell'organismo. ✔Facilità d'uso: l'integratore si presenta in compresse facili da deglutire, da assumere una volta al giorno. ●Cosa mi piace un po' meno: ✔Prezzo: Endotelio 1-MNA PRO è un prodotto costoso, soprattutto se confrontato con altri integratori sul mercato. 🙏Grazie per aver letto🙏 💖Mi auguro di cuore che questa mia recensione possa essere utile per te💖 👍Buona continuazione dei tuoi acquisti👍

Me encanta, llevo ya 3 potes y noto la piel y la energía

Das Produkt entspricht soweit der Beschreibung und macht einen hochwertigen Eindruck. Beworben wird es zur Optimierung des Energiehaushaltes und Steigerung des NAD+ Levels, laut Hersteller: 1-MNA spielt eine entscheidende Rolle bei der Regulierung des NAD-Stoffwechsels im Organismus, indem es das Enzym Nicotinamid-N-Methyltransferase (NNMT) blockiert, das ein wichtiger Regulator des empfindlichen Redox-Gleichgewichts ist, und so die Gesundheit der Zellen wiederherstellt und den NAD-Spiegel optimiert. Beim Menschen wird 1-MNA vor allem in der Leber während des Niacinstoffwechsels gebildet. Diese Produktion beruht auf dem enzymatischen Abbau von Nikotinamid, der durch die Nikotinamid-N-Methyltransferase (NNMT) erleichtert wird, vgl. Bild. D.h. SAM gibt seine Methylgruppe an Niacin = Vitamin B3 (NA) mit Hilfe des Enzyms NNMT ab und bildet dann 1-MNA und S-adenosyl-L- homocysteine (SAH), welches später zu Homocystein wird. Sowohl 1-MNA als auch S-adenosyl-L- homocysteine (SAH) wirken in höheren Konzentrationen negativ rückkoppelnd auf das Enzym NNMT und bremsen/ blockieren somit ihre eigene Erzeugung. Homocystein wird allerdings für Herz-Kreislauferkrankungen, Energiemangel und übermäßigen Entzündungen in Verbindung gebracht, während das Ausgangsprodukt SAM eher gegenteilig wirkt. Theoretisch kann der Körper/ die Leber Homocystein unter Energieaufwand mit B12 und Folsäure wieder zu SAM recyclen, praktisch aber oft auch nicht, vgl. 2tes Bild. SAM wirkt nebenbei auch stark antidepressiv, eine Nahrungsergänzung mit SAM wäre daher eine Option, hat aber m.E. den Nachteil, dass dann mit Vitamin B3 (Niacin) wieder auch vermehrt Homocystein gebildet wird. Der Ansatz, nur über 1-MNA das Enzym NNMT zu blockieren scheint mir genial, der SAM-Verbrauch sinkt, d.h. die SAM-Werte können sich eher auch ohne externe Zufuhr erholen und ohne das gleichzeitig mehr ungesundes Homocystein entsteht. Ein hoher Gehalt an freien Fettsäuren, z.B. durch Stress wie durch Fasten, Unterzuckerungen, Diabetes, regt das Enzym NNMT zusätzlich an, mit 1-MNA kann man dem entgegenwirken. Zu bevorzugen wäre natürlich die Bildung freier Fettsäuren erst gar nicht zu begünstigen und Stress z.B. auch durch Überanstrengung mit Unterzuckerungen zu reduzieren. Nahrungsquellen tragen leider nur minimal zur Gesamtmenge an 1-MNA im menschlichen Körper bei. Tatsächlich werden etwa 60 % des Niacins, das wir zu uns nehmen, in 1-MNA umgewandelt. Zu den Lebensmitteln, die einen bemerkenswerten Gehalt an 1-MNA aufweisen, gehören: Undaria pinnatifida (Wakame-Alge): 3,2 mg pro 100 g Blätter von grünem Tee: 3,0 mg pro 100 g Hähnchenmagen: 2,4 mg pro 100 g Staudensellerie: 1,6 mg pro 100 g Chinesische schwarze Pilze: 1,3 mg pro 100 g. Das aus Vitaminen gewonnene 1-MNA ist eine natürliche und physiologische Substanz. Es ist bekannt, dass es sicher und gut verträglich ist. Bekannt für seine entzündungshemmenden und anti-atherosklerotischen Eigenschaften. Senkt die Werte von Entzündungsmarkern. Wesentlich für die Aufrechterhaltung der Endothelfunktion der Gefäße und die Stimulierung der Synthese von Prostazyklin (PGI2). Fördert die Sekretionsfunktion des Gefäßendothels und schützt so vor Funktionsstörungen. Verringert das Risiko der Bildung von Blutgerinnseln und von Entzündungen durch die PGI2-Synthese. Gilt als ein bahnbrechendes Molekül mit starken entzündungshemmenden und atherosklerotischen Wirkungen. Meine Erfahrung: Ich hatte auch schon alle Niacinformen ohne Erfolg supplementiert, ist m.E. auch logisch, da Niacin mit SAMe zwar auch zu mehr 1-MNA führt, aber dann eben gleichzeitig auch zu mehr Homocystein und weniger SAMe, da SAMe dabei verbraucht wird. Dies will man ja gerade nicht. Ich habe daher früher auch lange Jahre SAM supplementiert, z.B. um die Entgiftung in der Leber zu unterstützen und die Glutathionwerte zu erhöhen, habe aber nun nach 3 Wochen 1-MNA bereits den Eindruck, dass 1-MNA bzgl. Energiehaushalt und Stimmung noch besser wirkt, was nach obigen Erläuterungen auch plausibel erscheint. Für die ganze Bandbreite positiver Wirkungen ist eine längere Einnahme sicher sinnvoll, habe daher bereits nachbestellt. Dafür 5 Sterne. Nachtrag nach einigen Monaten: Das 1-MNA ist echt super, habe bereits 6 x nachbestellt, für mich praktisch unverzichtbar. Ich komme mittlerweile auch mit 4 Kapseln pro Woche aus. Ein Wermutstropfen ist der aktuelle, hohe Preis von 55€ für 30 Kapseln mit 58 mg Wirkstoff. Ist m.E. sehr schade, dieses Produkt hätte eine weite Verbreitung verdient und könnte m.E. vielen Menschen helfen, aber bei dem Preis ist es nicht für jeden erschwinglich. Die Preispolitik ist wohl auch Folge eines neuen Vertriebsweges seit Anfang 2023, vorher gab es die gleiche Wirkstoffmenge für rund 1/5. Sehr bedauerlich.

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