Can you bypass the amp simulations and just use the different effects pedals?

I am fairly certain this will do exactly what I think you are asking. You can turn on/off every single stage independently and if you turn them all off it results in a plain vanilla guitar string pluck. If you then select reverb you'll get that vanilla pluck with reverb. This thing is like making a pizza. Use whatever toppings you want and there are no rules. I do all of my fiddling around with the settings using Boss Tone Studio. It works so much better for me that leaning over and squinting at knobs/dials. Enjoy.

Does this have a looping feature? If so, what is the maximum length of the loop that can be created?

There is a looper on the delay pedal. I believe it's 38 seconds, or at least in that ballpark.

Can you play through headaches without using a amp?

I tried but could not get it to do it. I still had to run my headphones trough the amp which is a pain when you have to drag it around just to practice or play with the settings.

Can I run the preamps through my real tube amp with no problems or is that only for amp simulation for without a amp? Don’t want to mess up my amp.

You should not "Mess" anything up but you will color the sound of the pre amp. Try to use it with as clean of a setting as you can.

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🎸 Unlock your signature sound with the ME-80 — where pro tone meets total control!

STAGE READY CONTROL - Eight multifunction footswitches plus expression pedal for real-time shaping
EFFORTLESS TONE SCULPTING - Knob-based interface lets you dial in pro sounds in seconds
EXPAND YOUR SONIC UNIVERSE - Free software and direct access to pro patches via BOSS TONE CENTRAL
SEAMLESS LOOPING CREATIVITY - 38-second phrase looper to build layers live and never miss a beat
ULTIMATE MULTI EFFECT POWER - Eight effect categories with classic and cutting-edge BOSS tones

The BOSS ME-80 is a compact, battery-powered multi-effects pedal featuring eight simultaneous effect categories, a 38-second phrase looper, and flagship COSM amps derived from the GT-100. Its intuitive knob-based interface and multifunction footswitches provide seamless control for live performance, while free BOSS TONE STUDIO software and access to BOSS TONE CENTRAL enable endless tone customization and patch downloads.

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