Does this work with Dell Optiplex 390?

The PEX1S553LP will work on any low profile / standard profile computer with an available PCI Express x1 slot or larger. As long as the computer has a PCI Express x1 slot or larger, the PEX1S553LP will work. Atha, StarTech.com Support

Does this card work with a dell optiplex 3040 sff?

The PEX1S553LP will work on any low profile / standard profile computer with an available PCI Express x1 slot or larger. As long as the computer has a PCI Express x1 slot or larger, the PEX1S553LP will work. Atha, StarTech.com Support

Is it necessary to connect the molex cable for it to work?

No if you are using windows 11 it won't work it seems even if you install the correct drivers it still won't work windows 11 has problems with serial ports

Will this work to connect an apc sua2200 ups?

The PEX1S553LP will work with RS232 Serial devices, which would include APC models that have serial connectivity. Brandon, StarTech.com Support

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Compatible Devices	Personal Computer
Operating System	Windows 7
Hardware Connectivity	PCI
Item Weight	0.04 Kilograms
Item Dimensions L x W x H	4.1"L x 3.1"W x 0.8"H
Style	Card

StarTech.com PEX1S553LP 1 Port Low Profile Native RS232 PCI Express Serial Card with 16550 UART

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